# How to Prepare a home-made Doxycycline Solution (a much cheaper alternative to Commercial Preparations)

How to Prepare a home-made Doxycycline Solution (a much cheaper alternative to commercial preparations)
Authored by Nong Obieta, November 26, 2017
How to Prepare a home-made Doxycycline Solution, a homemade much cheaper alternative to Doxyvet or Papi Doxy, which are usually recommended by many vet clinics.
Doxycycline is available in capsules or tablets The capsules are much cheaper, easier to use (the tablets can clog the throat of cats n kittens), and can be measured for exact dosage. The capsules come in 250mg per capsule, usually sold at P2.50 each.
Cats require a dosage of 5mg per kilo of body weight per dose every 12 hours, or a total of 10mg per kilo per dose per day,
Dogs require a dosage of 10mg per kilo of body weight per dose every 12 hours, or a total of 20mg per kilo per dose per day.
1) Take the powder from one capsule by slowly and very carefully twisting the 2 parts of the capsule, and make sure that ALL the powder from the capsule drops into a small glass, after which you will now have 100mg of Doxycycline powder in the glass (that’s 100mg per capsule). Add 5.0mL of mineral or purified water to the powder in the glass, and you now have a 5.0mL Doxycyline solution in the glass. PLEASE NOTE the difference between mg and mL.
and the dose should be given for NO LESS than 7 days, or a total of 14 doses, and, depending on the illness you are treating, could be up to 28 days(equivalent to a total of 56 doses) , as is the case with dogs suffering from serious ehrlichiosis (caused by ehrlichia). The dose should always be given every 12 hours, so choose the correct time to give the dose, like from 6am-9am for the morning dose, and from 6pm-9pm for the evening dose. NOTE: mg is not the same as mL NOTE: Vets in the USA usually recommend that doxycycline be given every 12 hours, although vets in Europe usually recommend that doxycycline be given only once a day. The choice is yours, depending on how much free time you have.
Doxycycline is best given after meals or on a full stomach for better absorption, but it is not a requirement. Doxycycline is extremely bitter, so it is best to add water (not to the 5mL solution) but only to the amount you will be giving to your animals. So if you compute the requirement of a specific animal as 1.5mL per dose, for example, then add water only to the 1.5mL and not to the 5mL solution you had prepared with one capsule.
So, follow these examples below to be able to compute correctly:
Example #1: Dog weighs 17.5 kilos, then
a) 17.5 x 10mg = 175mg is what you will need to give the dog per dose, so you need to mix at least 2 pieces of 100mg capsules, for a total of 200mg, since 1 capsule will only produce 100mg.
b) then, since you have to mix 5mL of clean water for every 100mg, or for every capsule, in this case you have to add 10mL of water to the powder taken from two capsules.
c) then, since you have to compute how much mL (not mg) you have to give your dog, you have to compute 175mg divided by 200mg, which will result in 0.875, which you will then have to multiply by 10, since you now have a 10mL solution, and you will get the result of 8.75mL, which is the amount you have to give your dog every 12 hours for at least 7 days, and perhaps longer depending on what you are treating the dog for.
Example #2: Cat weighs 1.80 kilos, then
a) 1.80 x 5mg = 9.0mg, so you need to mix only one 100mg capsule
b) then, since you have to mix 5mL of clean water for every 100mg, then add only 5mL of water
c) then, since you have to compute how much mL (not mg) you have to give your cat, you have to compute 9.0mg divided by 100mg, which will result in 0.09%, which you will then have to multiply by 5, since you now have a 5mL solution, and you will get the result of 0.45mL, which is the amount you have to give your cat every 12 hours for at least 7 days, and perhaps longer depending on what you are treating the cat for.
A Doxycline solution can be kept at room temperature for 14 days, and should NOT be refrigerated. Any remaining solution should be discarded after 14 days.
That’s it, it is truly as simple as that.
Note that you assume ALL risks and consequences by following this suggested solution, and Nong Obieta and PAWA cannot be held liable for any reason.